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Mandana Veiseh

Mandana Veiseh is a senior scientist and area manager of Bioengineered Devices and Systems at the Electronic Materials and Devices Laboratory, enabling development and characterization of functional biohybrid materials, devices and systems for health and environment. Research in her group bridges engineering and nanotechnology to translational biosciences in the areas of cancer diagnosis and heterogeneity profiling, bioelectronics medicine (biosensing and biomarker discovery), drug delivery devices, 3D bioprinting and bioimaging, and 3D model systems. With a broad experience in managing multi-disciplinary projects/teams, government business development, and grant writing, her work has contributed to the development of new scientific venues as well as the launch and success of two startup companies, where she acted as scientific co-founder, co-inventor, and advisor.

Prior to joining PARC, Mandana worked as a scientist and a National Research Service Award fellow of the National Cancer Institute at Lawrence Berkeley National Laboratory (LBNL), where she developed microenvironmental probes and physiologically relevant 3D micro-electromechanical systems (MEMS), and discovered a new type of cellular and functional heterogeneity within metastatic breast cancers. She also led the LBNL Early Career Scientists Society and initiated new research directions as part of the biosciences strategic planning. Her postdoctoral work at Fred Hutchinson Cancer Research Center, Tumor Paint for precise brain cancer demarcation and a drug delivery technology to improve cancer drug development process, have both proceeded to human clinical trials.

Dr. Veiseh's dual Ph.D. studies in Materials Science & Engineering and Nanotechnology at University of Washington (UW) focused on development of a surface molecular engineering method on MEMS for design of cell-based biosensors, which were applied for label-free bacterial analyte detection through her Department of Energy-Advanced Light Source fellowship at LBNL and UC Berkeley. She holds B.Sc. and M.Sc. in Textile Chemical Engineering from Tehran Polytechnic and Isfahan University of Technology with a focus on dye chemistry and fluorescent color-matching by neural networks. She has multidisciplinary publications (garnering over 1250 citations), inventions, presentations, and awards including: ASME Global Congress on Nanoengineering for Medicine and Biology - Outstanding Paper Award; Jordyn Dukelow Fellowship in Pediatric Neuro-oncology Research; Society of Women Engineers - Outstanding Graduate Award; and selection to participate in the 2015 U.S. Frontiers of Engineering Symposium - National Academy of Engineering.

Mandana enjoys outdoor family activities, swimming, music, and reading.


PARC publications

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MicroArray Ballistic Drug Delivery

DNA Vaccines 2014

21 July 2014



other publications

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Uncovering the dual role of RHAMM as an HA receptor and a regulator of CD44 expression in RHAMM-expressing mesenchymal progenitor cells

Mandana Veiseh, Sean Leith, Cornelia Tolg, Bahram Bahrami, Lisa Collis, Sara Hamilton, James McCarthy, Mina J. Bissell and Eva Turley Frontiers in Cell and Developmental Biology

09 October 2015

A technology platform to assess multiple cancer agents simultaneously within a patient's tumor

R.A. Klinghoffer, S.B. Bahrami , B.A.Hatton, J.P. Frazier, A. Moreno-Gonzalez, A.D. Strand, W.S. Kerwin, J.R. Casalini, D.J. Thirstrup, S. You, S.M. Morris, K.L. Watts, M. Veiseh, M.O. Grenley, I. Tretyak, J. Dey, M. Carleton, E. Beirne,K.D. Pedro, S.H. Ditzler, E.J. Girard, T.L. Deckwerth, J.A. Bertout, K.A. Meleo, E.H. Filvaroff, R. Chopra, O.W. Press, J.M. Olson Science Translational Medicine

22 April 2015

Capturing cancer’s complexity

S. C. P. Williams (News feature on Veiseh et. al., PNAS, April 14 2014 publication) Proceedings of the National Academy of Sciences of the United States of America

14 April 2015


From Microenvironment to Nanoenvironment: Ultrastructure and Function of Extracellular Matrix

Mandana Veiseh , Arya Nikjoo , Eva A . Turley , and Mina J . Bissell Nanotechnology and Regenerative Engineering:The Scaffold

Cellular heterogeneity profiling by hyaluronan probes reveals an invasive but slow-growing breast tumor subset

M. Veiseh, D.H. Kwon, A.D. Borowsky, C. Tolg, H.S. Leong, J.D. Lewis, E.A. Turley, M.J. Bissell. Proceedings of the National Academy of Sciences of the United States of America

Tumor microenvironmental probes: multivalent detectors of functional and cellular heterogeneity within aggressive cancers

M. Veiseh, E.A. Turley, M.J. Bissell. ASME 2014 3rd Global Congress on Nanoengineering for Medicine and Biology

5 February 2014


Uncovering aggressive cancer cell heterogeneity by tumor microenvironmental glyco-conjugates

M. Veiseh, E.A. Turley, M.J. Bissell. Biomedical Engineering Society Annual Meeting

28 September 2013

Hyaluronan-based microenvironmental probes distinguish heterogeneous breast cancer cell subsets and predict their invasive behavior

M. Veiseh, E.A. Turley, M.J. Bissell. ASME 2013 2nd Global Congress on Nanoengineering for Medicine and Biology


Engineering a drug delivery platform for multiplexed in vivo cancer therapeutics screening and pathway analyses

S.B. Bahrami, M. Veiseh, J.M. Olson. ASME 2013 2nd Global Congress on Nanoengineering for Medicine and Biology



Imaging of homeostatic, neoplastic and injured tissues by HA-based probes

M. Veiseh, D. Breadner, N. Akentieva, R.C. Savani, R.E. Harrison, D. Mikilus, L. Collis, T.Y. Lee, J. Koropatnick, L.G. Luyt, M.J. Bissell, E.A. Turley. Biomacromolecules

Isolation and expansion of endothelial progenitor cells derived from mouse embryonic stem cells

S.B. Bahrami, M. Veiseh, N.J. Boudreau. Progenitor Cells: Methods and Protocols, Methods in Molecular Biology


Temporal changes in hox gene expression accompany endothelial cell differentiation of embryonic stem cells

S.B. Bahrami, M. Veiseh, A.A. Dunn, N.J. Boudreau. Cell Adhesion & Migration


Sustained activation of STAT5 is essential for chromatin remodeling and maintenance of mammary-specific function

R. Xu, C.M. Nelson, J.L. Muschler, M. Veiseh, B.K. Vonderhaar, M.J. Bissell. Journal of Cell Biology

Pharmacokinetics and pharmacodynamics of hyaluronan infused into healthy human volunteers

S.R. Hamilton*, M. Veiseh*, C. Tölg*, R.G. Tirona, J. Richardson, R. Brown, M. Gonzalez, M. Vanzieleghem, P. Anderson, S.S. Asculai, F. Winnik, R.C. Savani, D. Freeman, L. Luyt, J. Koropatnick, E.A. Turley. The Open Drug Metabolism Journal


A top-down analysis of a dynamic environment: extracellular matrix structure and function

M. Veiseh, E.A. Turley, M.J. Bissell. Nanotechnology and Tissue Engineering: The Scaffold

Mechanisms of disease: epithelial–mesenchymal transition and back again: does cellular plasticity fuel neoplastic progression?

E.A. Turley, M. Veiseh, D.C. Radisky, M.J. Bissell. Nature Reviews Clinical Practice Oncology

Influence of cell adhesion and spreading on impedance characteristics of cell-based sensors

F. Asphahani, M. Thein, O. Veiseh, D. Edmondson, R. Kosai, M. Veiseh, J. Xu, M. Zhang. Biosensors & Bioelectronics


Single-cell-based sensors and synchrotron FTIR spectroscopy: a hybrid system towards bacterial detection

M. Veiseh, O. Veiseh, M.C. Martin, C.R. Bertozzi, M. Zhang. Biosensors & Bioelectronics

Tumor paint: a chlorotoxin: Cy5.5 bioconjugate for intraoperative visualization of cancer foci

M. Veiseh*, P. Gabikian*, S.B. Bahrami, O. Veiseh, M. Zhang, R.C. Hackman, A.C. Ravanpay, M.R. Stroud, Y. Kusuma, S.J. Hansen, D. Kwok, N.M. Munoz, R.W. Sze, W.M. Grady, N.M. Greenberg, R.G. Ellenbogen, J.M. Olson. Cancer Research

The hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1,2, which sustain high basal motility in breast cancer cells

S.R. Hamilton, S.F. Fard, F.F. Paiwand, C. Tolg, M. Veiseh, C. Wang, J.B. McCarthy, M.J. Bissell, J. Koropatnick, E.A. Turley. Journal of Biological Chemistry

Short peptides enhance single-cell adhesion and viability on microarrays

M. Veiseh, O. Veiseh, M.C. Martin, F. Asphahani, M. Zhang. Langmuir


Effect of silicon oxidation on long-term cell selectivity of cell-patterned Au/SiO2 platforms

M. Veiseh, M. Zhang. Journal of the American Chemical Society



Guided cell patterning on gold-silicon dioxide substrates by surface molecular engineering

M. Veiseh, B.T. Wickes, D.G. Castner, M. Zhang. Biomaterials




Micro-patterning of individual cell growth for cell-based sensor applications

M. Veiseh, Y. Zhang and M. Zhang. BioMEMS and Biomedical Nanotechnology World 2000 Conference



Application of neural network in color matching of fluorescent samples

S.H. Amirshahi, F. Torkamani-Azar, M. Veiseh. 7th National Conference of Electrical Engineering in Iran



Dyeing with Reactive Dyes

N. Saadatjou, M. Arami, M. Veiseh. Amirkabir Journal of Science and Technology




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