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EVENT:

Spectrum Fusion: Using Multiple Mass Spectra for De Novo Peptide Sequencing
Conferences & Talks

12th Annual International Conference on Research in Computational Molecular Biology (RECOMB2008)

30 March 2008 - 2 April 2008
Singapore

 

description

We report on a new algorithm for combining the information from several mass spectra of the same peptide. The algorithm automatically learns peptide fragmentation patterns, so that it can handle spectra from any instrument and fragmentation technique. We demonstrate the utility of the algorithm, and the power of multiple spectra, by showing that combining pairs of spectra (one CID and one ETD) greatly improves de novo sequencing success rates.