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Bio-sensor arrays on flexible polyimide substrates for drug discovery applications

 

PARC's enthalpy arrays are designed to provide a high-throughput, label-less assay methodology for screening and thermodynamically analyzing molecular interactions while effectively eliminating need for specific assay development. The enthalpy arrays are used to detect molecular interactions involving proteins, ligands, RNA, DNA and other bio molecules for proteomic research and drug discovery. Each enthalpy array consists of 96 individual bio sensors and is fabricated on thin flexible kapton substrates using micro scale technologies to reduce the device cost. In this talk we will discuss the sensor design, architecture, and materials selection. We will describe the device optimization and show how we can detect reactions with sub-milidegree temperature variation using reagent sample sizes of 250nl at concentrations in the low tens of micromolar. The reduced sample quantity and measurement time offer major improvement over conventional microcalorimetry.

 
citation

Wolkin, M. V. ; De Bruyker, D. ; Anderson, G. B. ; Peeters, E. ; Torres, F. ; Recht, M. I. ; Bell, A. G. ; Bruce, R. H. Bio-sensor arrays on flexible polyimide substrates for drug discovery applications. Spring Meeting of the Materials Research Society; 2006 April; San Francisco; CA; USA.