A smart bioprinter for tissue engineering
Ink jetting is a collection of various drop ejection concepts; many of them are mature technologies used in the imaging and document business. In recent years, inkjet printing has been used to fabricate micro bio-arrays and tissue constructs using biological substances ("bioink") from nucleic acids and antibodies to cells and extra-cellular matrix, collagen or other cellular regulatory or stimulatory factors. Ink jetting of biological materials is advantageous in speed, resolution, and scalability compared to pin-based methods and is more customizable and scaleable than photolithography processes for the array-creation purpose. For printing cells, tissues or organ constructs, drop ejection methods, in particular ink jetting, are preferred due to the complexity and labile nature of the bioink. The Palo Alto Research Center has many years of expertise in developing piezoelectric inkjet printing for Xerox, and has created a specialized version of a piezoelectric inkjet printer for use as a bioprinter.
Hsieh, H. B. A smart bioprinter for tissue engineering. Third International Symposium on Bioprinting and Biofabrication; 2006 November 21-22; Kawasaki; Japan.