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Novel membrane-free bio-agents separation by asymmetric inertial migration

 

BWAs are typically dispersed in the field at concentrations below the LOD of most sensor technologies. Conventional screening methods involve multiple stages of TFF to capture retentate for detection. Since all particulates are captured, TOC contributes to serious obscuration problems to the detector. We present a new scalable, high throughput, continuous flow bio-agent separation technology based solely on intrinsic flow characteristics in curvilinear channels. Dispersed particles in laminar flow through the curvilinear channel make transverse migrations and become ordered streams for micro-separation without membranes or external force fields. Particles above the designed cut-off size are collected at one bifurcated outlet.

 
citation

Seo, J. ; Lean, M. ; Kole, A. Novel membrane-free bio-agents separation by asymmetric inertial migration. Nanoelectronic Devices for Defense & Security Conference; 2007 June 18-21; Crystal City, VA USA.