Spectrum fusion: using multiple mass spectra for de novo peptide sequencing
We report on a new algorithm for combining the information from several mass spectra of the same peptide. The algorithm automatically learns peptide fragmentation patterns, so that it can handle spectra from any instrument and fragmentation technique. We demonstrate the utility of the algorithm, and the power of multiple spectra, by showing that combining pairs of spectra (one CID and one ETD) greatly improves de novo sequencing success rates.
Bern, M. W. ; Datta, R. Spectrum fusion: using multiple mass spectra for de novo peptide sequencing. Research in Computational Molecular Biology, Twelfth Annual International Conference (RECOMB 2008); 2008 March 30 - April 2; Singapore. Berlin: Springer; 2008; LNCS 4955: 140-153.