MicroArray Ballistic Drug Delivery
Particle based drug delivery uses mechanical force to penetrate into cells. Biochemical techniques for cell penetration require complex formulations, and electroporation can cause irreversible tissue damage and potential destabilization of therapeutic material. In contrast, ballistic delivery relies on physical properties of the particles, potentially enabling simpler formulations and delivery strategies. However, particle based ballistic delivery is not currently available for mainstream human use due to problems with control (e.g. sporadic bleeding, repeatability, etc.), loud noise (explosive), and low dosing capability. We describe a disposable microarray ballistic aerosol drug delivery device enabling on-demand transdermal delivery of drug particles through needle-free injections. Our delivery platform is explosion free and has the potential for higher delivery dosages and significantly improved tissue depth and spatial control compared to previous particle delivery systems (shock-tube based ballistic liquid jet/solid particle). The device creates continuous and finely tunable arrays of laser-like beams of drug particles that have been entrained into high speed collimated air jets. Similar to printing, the architecture allows for scanning target skin for large area/dose delivery and is scalable to smaller form factors. Drug particles can be directly targeted to physical locations, such as epidermal Langerhans cells for vaccines, and to depths restricted to nerve-less regions (painless). Our platform allows for delivery of a broad range of drugs, but it is particularly advantageous for transdermal delivery of DNA/RNA based therapies for intracellular delivery (e.g. vaccines).
Pirmoradi, F.; Linn, F.; Recht, M.; Volkel, A. R.; Kjono, S.; Veiseh, M.; Anderson, G. B.; Pattekar, A. V.; Peeters, E.; Uhland, S.A.; Chow, E. M. MicroArray Ballistic Drug Delivery. DNA Vaccines 2014.