Advances in calorimetry for drug discovery
Details
Speakers
Advances in calorimetry for drug discovery
Calorimetry is a universally applicable label-free and immobilization-free method that directly measures heat changes associated with binding interactions, enzymatic reactions, cell growth, and macromolecule folding and stability. Isothermal titration calorimetry (ITC), the only method that can simultaneously determine all binding parameters (enthalpy, entropy, affinity, and number of sites) in a single experiment, has long been regarded as the gold standard assay for binding. Due to the low throughput and relatively large quantities of material required for the measurements, the application of ITC in drug discovery has been limited.
This presentation looks at the advances in the miniaturization of calorimeters and how the increased throughput and reduced sample consumption of these devices could expand the application of calorimetry in drug discovery.
Additional information
Our work is centered around a series of Focus Areas that we believe are the future of science and technology.
We’re continually developing new technologies, many of which are available for Commercialization.
PARC scientists and staffers are active members and contributors to the science and technology communities.