Constrained de novo sequencing of peptides with applications to conotoxins
Details
2011 March 28-31; Vancouver, BC, Canada
Speakers
Marshall Bern
Event
Constrained de novo sequencing of peptides with applications to conotoxins
Cone snail toxins are small (10 -- 40 aa), heavily modified, cysteine-rich proteins. They are of special interest as drug leads and as probes for studying ion channels. With advances such as ETD fragmentation and high-accuracy MS/MS, it's just now becoming feasible to sequence these molecules by mass spectrometry. I'll talk about a bioinformatics approach suitable for the problem: constrained de novo sequencing, which generates and scores candidate sequences matching user-defined constraints. The constraints can vary from simple ("must contain four cysteines") to complex (a regular expression or hidden Markov model).
Additional information
Focus Areas
Our work is centered around a series of Focus Areas that we believe are the future of science and technology.
Licensing & Commercialization Opportunities
We’re continually developing new technologies, many of which are available for Commercialization.
News
PARC scientists and staffers are active members and contributors to the science and technology communities.