Constrained de novo sequencing of peptides with applications to conotoxins

Details

2011 March 28-31; Vancouver, BC, Canada

Speakers

Marshall Bern
Event

Constrained de novo sequencing of peptides with applications to conotoxins

Cone snail toxins are small (10 -- 40 aa), heavily modified, cysteine-rich proteins. They are of special interest as drug leads and as probes for studying ion channels. With advances such as ETD fragmentation and high-accuracy MS/MS, it's just now becoming feasible to sequence these molecules by mass spectrometry. I'll talk about a bioinformatics approach suitable for the problem: constrained de novo sequencing, which generates and scores candidate sequences matching user-defined constraints. The constraints can vary from simple ("must contain four cysteines") to complex (a regular expression or hidden Markov model).

Additional information

Focus Areas

Our work is centered around a series of Focus Areas that we believe are the future of science and technology.

FIND OUT MORE
Licensing & Commercialization Opportunities

We’re continually developing new technologies, many of which are available forĀ Commercialization.

FIND OUT MORE
News

PARC scientists and staffers are active members and contributors to the science and technology communities.

FIND OUT MORE