Development of novel arrayed microjet devices for transdermal drug administration

Details

Event 40th Annual Meeting & Exposition of the Controlled Release Society

Authors

Hsieh, Huangpin B.
Pattekar, Ashish V.
Scott Uhland
Armin R. Volkel
Recht, Michael I.
Felicia Linn
Greg Anderson
Technical Publications
July 23rd 2013
The micro-arrayed needle-free injector technology being developed for trans-dermal vaccine administration is based on PARCs work on ballistic aerosol marking, which was originally developed as an alternative to conventional ink-jet printing. The underlying idea behind it was to use high speed air jets (at sonic to supersonic speeds) in order to accelerate entrained toner particles at sufficiently high speeds such that their kinetic energy would be sufficient to cause instant melting and fusing to the paper upon impact, thereby creating a pixel for print/imaging applications. This multi-year effort resulted in the development of a number of devices capable of producing high-speed air jets using microchannel-based arrayed venturi structures that were shown to successfully create print images using toner particles (typically in the size range of 4 to 8 m). Recently, we have also successfully used such approach to deliver liquid jets. In this paper we describe a project to leverage this technology and PARCs significant know-how in this area to develop novel drug delivery devices for transdermal administration of encapsulated powder vaccines.

Citation

Hsieh, H. B.; Pattekar, A. V.; Uhland, S.; Volkel, A. R.; Recht, M. I.; Linn, F.; Anderson, G. B.; Chow, E. M. Development of novel arrayed microjet devices for transdermal drug administration. 40th Annual Meeting & Exposition of the Controlled Release Society; 2013 July 21-24; Honolulu, HI.

Additional information

Focus Areas

Our work is centered around a series of Focus Areas that we believe are the future of science and technology.

FIND OUT MORE
Licensing & Commercialization Opportunities

We’re continually developing new technologies, many of which are available for¬†Commercialization.

FIND OUT MORE
News

PARC scientists and staffers are active members and contributors to the science and technology communities.

FIND OUT MORE