Microfluidic-based detection platform for on-the-flow analyte characterization

While commercial flow cytometers are sophisticated analytical instruments extensively used in research and clinical laboratories, they do not meet the challenging practical requirements for point-of-care (POC) diagnostics. In this paper we will describe and illustrate a new detection technique that will enable a compact, microfluidic-based flow cytometer that satisfies POC specifications for performance, robustness, compactness, cost, reagent consumption, and ease of use. The technology has been demonstrated with CD4 counts in whole blood.

Citation

Kiesel, P.; Beck, M.; Johnson, N. M.; Bassler, M. Microfluidic-based detection platform for on-the-flow analyte characterization. Silicon Photonics V at OPTO 2010; 2010 January 23-28; San Francisco, CA. SPIE Proceedings 7606: 760608.