Spatially modulated emission advances point-of-care diagnostics

Details

Event Laser Focus World

Authors

Markus Beck
Malte Huck
Marshall Bern
Noble Johnson
Technical Publications
November 12th 2010
Most biomedical tests are performed at large clinical laboratories because compact, robust, and inexpensive instruments for point-of-care (POC) testing are simply not available. Yet there is a need for POC testing. Optofluidic systems for fluorescence detection of bio-particles offer high performance, but they cannot meet POC specifications. We have demonstrated, prototyped, and benchmarked against commercial systems a new optical detection approach that delivers high signal-to-noise discrimination without complex optics or bulky excitation sources. It therefore enables a truly compact, low-cost, high-performance microfluidic-based instrument that can be used for CD4 diagnostics on whole blood and for other complex biological fluids.

Citation

Kiesel, P.; Martini, J.; Beck, M.; Huck, M.; Bern, M. W.; Johnson, N. M. Spatially modulated emission advances point-of-care diagnostics. Laser Focus World. 2010 November; 15 (10): 47-50.

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