Spectrum fusion: using multiple mass spectra for de novo peptide sequencing

Details

Event Journal of Computational Biology

Authors

Marshall Bern
Technical Publications
August 1st 2009
We report on a new algorithm for combining the information from several mass spectra of the same peptide. The algorithm automatically learns peptide fragmentation patterns, so that it can handle spectra from any instrument and fragmentation technique. We demonstrate the utility of the algorithm, and the power of multiple spectra, by showing that combining pairs of spectra (one CID and one ETD) greatly improves de novo sequencing success rates.

Citation

Datta, R.; Bern, M. W. Spectrum fusion: using multiple mass spectra for de novo peptide sequencing. Journal of Computational Biology. 2009 August; 16 (8): 1169-1182.

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